I just came across this link from Brooklyn Magazine, called "Literary United States: A Map of the Best Book for Every State." What an idea! I kind of like the thought of reading your way through the USA, particularly when you're stuck in a Midwestern winter like the one heading my way in the far-too-near future.
I've read 9 of the 53 books on the list. Looks like I've got some work to do this winter.